Lipitor En Français
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However, time of administration does not affect the Lipitor en Français LDL-C-lowering efficacy of atorvastatin. Distribution[ edit ] The mean volume of distribution of atorvastatin is approximately L. Metabolism[ edit ] Atorvastatin metabolism is primarily through cytochrome P 3A4 hydroxylation to form active ortho- and parahydroxylated metabolitesas well as various beta-oxidation metabolites. The ortho-hydroxy metabolite undergoes further metabolism via glucuronidation.
What is Lipitor?
As a substrate for the CYP3A4 isozyme, it has shown Lipitor en Français to inhibitors and inducers of CYP3A4 to produce increased or decreased plasma concentrations, respectively. This interaction was tested in vitro with concurrent administration of erythromycina known CYP3A4 isozyme inhibitor, which resulted in increased plasma concentrations of atorvastatin.
It is also an inhibitor of cytochrome 3A4. There does not appear to be any entero-hepatic Lipitor en Français. Atorvastatin has an approximate elimination half-life of 14 hours.
Noteworthy, the HMG-CoA reductase inhibitory activity appears to have a half-life of 20—30 hours, which is thought to be due to the active metabolites. Atorvastatin is also a substrate of the intestinal P-glycoprotein efflux transporter, which pumps the medication back into the intestinal lumen during medication absorption.
Additionally, healthy elderly people show a greater pharmacodynamic response to atorvastatin at any Lipitor en Français therefore, this population may have lower effective doses.
This phenomenon is suspected to be related to increased plasma levels of pharmacologically active metabolites, Lipitor En Français, such as atorvastatin lactone and p-hydroxyatorvastatin.
Do not use this medicine in larger or smaller amounts or for longer than recommended. Lipitor is usually taken once a day, with or without food.
Take the medicine at the same time each day. Do not break an Lipitor tablet before taking it. You may need to stop using this medicine for a Lipitor en Français time if you have: It may take up to 2 weeks before your cholesterol levels improve, and you may need frequent blood test. Even if you have no symptoms, tests can help your doctor determine if Lipitor is effective.
Lipitor is only part of a complete Lipitor en Français program that may also include diet, exercise, and weight control. Follow your doctor’s instructions very closely. Store at room temperature away from moisture, heat, and light. Lipitor dosage information in more detail What happens if I miss a dose?
Chimie et mécanisme d’action
Take the missed Lipitor en Français as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose. What happens if I overdose?
Seek emergency medical attention or Lipitor en Français the Poison Help line at What should I avoid while taking Lipitor?
Avoid eating foods that are high in fat or cholesterol. Lipitor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.